2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aminoacyl-tRNA Synthetase

Aminoacyl-tRNA Synthetase

tRNA Synthetase, aaRS

Aminoacyl-tRNA Synthetase

Related Products

PDF 0.17 MB

Aminoacyl-tRNA synthetases (AARSs) are the enzymes that catalyze the aminoacylation reaction by covalently linking an amino acid to its cognate tRNA in the first step of protein translation. In mammals, AARSs usually exist in free form or in the form of a multi-tRNA synthetase complex (MSC), and the latter consists of eight AARSs and three non-enzymatic AARS-interacting multi-functional proteins (AIMP1/p43, AIMP2/p38, and AIMP3/p18).

AARSs are responsible for the proper pairing of codons on mRNA with amino acids. AARSs are also involved in RNA splicing, transcriptional regulation, translation, and other aspects of cellular homeostasis. Study of these enzymes is of great interest to the researchers due to its pivotal role in the growth and survival of an organism. AARSs are one of the leading targets for developing novel anti-infective agents. Further, unfolding the interesting structural and functional aspects of these enzymes in the last few years has qualified them as a potential drug target against various diseases.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-147674
    Isoleucyl tRNA synthetase-IN-2
    		Inhibitor
    Isoleucyl tRNA synthetase-IN-2 (compound 36a) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a Ki,app of 114 nM.
    Isoleucyl tRNA synthetase-IN-2
  • HY-139657
    ThrRS-IN-2
    		Inhibitor
    ThrRS-IN-2 is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 value of 56.5 ± 3.5 μM.
    ThrRS-IN-2
  • HY-108900A
    Leu-AMS R enantiomer
    Leu-AMS R enantiomer is the R enatiomer of Leu-AMS. Leu-AMS is a potent inhibitor of leucyl-tRNA synthetase (LRS) and inhibits the growth of bacteria.
    Leu-AMS R enantiomer
  • HY-W142169
    N-Formyl-L-histidine
    N-Formyl-L-histidine shows binding affinity to histidyl-tRNA synthetase with a Ki value of 4.6 μM. N-Formyl-L-histidine shows a competitive inhibition against L-histidine ammonia-lyase, inhibits urocanic acid formation from L-histidine with a Ki value of 4.26 mM.
    N-Formyl-L-histidine
  • HY-15782
    YH16899
    		Inhibitor
    YH16899 binds Lysyl-tRNA synthetase (KRS), and inhibits membrane translocation of KRS. YH16899 impares the interaction of KRS with 67LR. YH16899 inhibits tumor metastasis in mouse models.
    YH16899
  • HY-103280
    LysRs-IN-1
    		Inhibitor 98.64%
    LysRs-IN-1 is a Lysyl-tRNA synthetase (LysRs) inhibitor.
    LysRs-IN-1
  • HY-162371
    NRPSs-IN-1
    NRPSs-IN-1 (Compound 7) is a cell-penetrating inhibitor of non-ribosomal peptide synthetase (NRPSs). NRPSs-IN-1 K inhibits gramicidin S synthetase A (GrsA) with a Kd value of 16.6 nM.
    NRPSs-IN-1
  • HY-147672
    IleRS-IN-1
    		Inhibitor
    IleRS-IN-1 (compound 11) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a Ki,app of 88 nM.
    IleRS-IN-1
  • HY-117938
    T-3861174
    		Inhibitor
    T-3861174 is an inhibitor of prolyl-tRNA synthetase (PRS, Aminoacyl-tRNA Synthetase) without completely inhibiting its translation process. T-3861174 activates the GCN2-ATF4 pathway and induces death in multiple tumor cell lines, including SK-MEL-2. T-3861174 demonstrated significant antitumor activity in multiple xenograft models without significantly affecting body weight.
    T-3861174
  • HY-147671
    CB 168
    		Inhibitor
    CB 168 is a potent and selective aminoacyl-sulfamoyl aryltetrazole inhibitor targeting isoleucyl-tRNA synthetase (IleRS).
    CB 168
  • HY-163457
    Antileishmanial agent-27
    		Inhibitor
    Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC50 values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties.
    Antileishmanial agent-27
  • HY-160127
    SerSA
    SerSA is a potent inhibitor of seryl-tRNA synthetases. SerSA inhibits EcSerRS, SaSerRS and HsSerRS with IC50s of 0.21, 0.23 and 2.17 μM, respectively.
    SerSA
  • HY-159103
    LeuRS-IN-2
    		Inhibitor
    LeuRS-IN-2 (Compound 9) is a Wolbachia leucyl-tRNA synthetase (LeuRS) inhibitor in the presence of adenosine monophosphate (AMP) with an EC50 value of 6 nM, efficiently arresting the growth of pathogenic host. LeuRS-IN-2 forms adenosine-based adducts inhibiting protein synthesis, which is promising for research of new antimicrobials with disrupting microbiota.
    LeuRS-IN-2
  • HY-168569
    DDD489
    		Inhibitor
    DDD489 is a potent and selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 values of 0.85 uM.DDD489 shows anti-cryptosporidials activity in vitro and in vivo.
    DDD489
  • HY-161797
    Antibacterial agent 227
    		Inhibitor
    Antibacterial agent 227 (Compd 29) is a SerRS (Seryl-tRNA synthetase) inhibitor. Antibacterial agent 227 has a significant inhibitory effect on the growth of planktonic and biofilm culture of Staphylococcus aureus 25923 with MIC (minimum inhibitory concentration) value of 32 µg/ml. Antibacterial agent 227 can be proposed as effective antiseptic toward multidrug-resistant biofilm-forming S. aureus isolates.
    Antibacterial agent 227
  • HY-12479B
    Epetraborole (R-mandelate)
    		Inhibitor
    Epetraborole R-mandelate is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole R-mandelate can be used in multidrug-resistant gram-negative pathogens infection research.
    Epetraborole (R-mandelate)
  • HY-161800
    Aminoacyl tRNA synthetase-IN-3
    		Inhibitor
    Aminoacyl tRNA synthetase-IN-3 (compound 36K3) is an inhibitor of lysine tRNA synthetase (PfLysRS) from Plasmodium falciparum (IC50=59.2 nM), which inhibits the activity of PfLysRS by occupying the ATP binding site and L-lysine binding site of PfLysRS. Aminoacyl tRNA synthetase-IN-3 can be used in the development of antimalarial drugs.
    Aminoacyl tRNA synthetase-IN-3
Cat. No. Product Name / Synonyms Application Reactivity