2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aminoacyl-tRNA Synthetase

Aminoacyl-tRNA Synthetase

tRNA Synthetase, aaRS

Aminoacyl-tRNA Synthetase

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Aminoacyl-tRNA synthetases (AARSs) are the enzymes that catalyze the aminoacylation reaction by covalently linking an amino acid to its cognate tRNA in the first step of protein translation. In mammals, AARSs usually exist in free form or in the form of a multi-tRNA synthetase complex (MSC), and the latter consists of eight AARSs and three non-enzymatic AARS-interacting multi-functional proteins (AIMP1/p43, AIMP2/p38, and AIMP3/p18).

AARSs are responsible for the proper pairing of codons on mRNA with amino acids. AARSs are also involved in RNA splicing, transcriptional regulation, translation, and other aspects of cellular homeostasis. Study of these enzymes is of great interest to the researchers due to its pivotal role in the growth and survival of an organism. AARSs are one of the leading targets for developing novel anti-infective agents. Further, unfolding the interesting structural and functional aspects of these enzymes in the last few years has qualified them as a potential drug target against various diseases.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-117938
    T-3861174
    		Inhibitor
    T-3861174 is an inhibitor of prolyl-tRNA synthetase (PRS, Aminoacyl-tRNA Synthetase) without completely inhibiting its translation process. T-3861174 activates the GCN2-ATF4 pathway and induces death in multiple tumor cell lines, including SK-MEL-2. T-3861174 demonstrated significant antitumor activity in multiple xenograft models without significantly affecting body weight.
    T-3861174
  • HY-147671
    CB 168
    		Inhibitor
    CB 168 is a potent and selective aminoacyl-sulfamoyl aryltetrazole inhibitor targeting isoleucyl-tRNA synthetase (IleRS).
    CB 168
  • HY-163457
    Antileishmanial agent-27
    		Inhibitor
    Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC50 values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties.
    Antileishmanial agent-27
  • HY-159103
    LeuRS-IN-2
    		Inhibitor
    LeuRS-IN-2 (Compound 9) is a Wolbachia leucyl-tRNA synthetase (LeuRS) inhibitor in the presence of adenosine monophosphate (AMP) with an EC50 value of 6 nM, efficiently arresting the growth of pathogenic host. LeuRS-IN-2 forms adenosine-based adducts inhibiting protein synthesis, which is promising for research of new antimicrobials with disrupting microbiota.
    LeuRS-IN-2
  • HY-161797
    Antibacterial agent 227
    		Inhibitor
    Antibacterial agent 227 (Compd 29) is a SerRS (Seryl-tRNA synthetase) inhibitor. Antibacterial agent 227 has a significant inhibitory effect on the growth of planktonic and biofilm culture of Staphylococcus aureus 25923 with MIC (minimum inhibitory concentration) value of 32 µg/ml. Antibacterial agent 227 can be proposed as effective antiseptic toward multidrug-resistant biofilm-forming S. aureus isolates.
    Antibacterial agent 227
  • HY-161799
    LysRs-IN-3
    		Inhibitor
    LysRs-IN-3 (compound 36) is an inhibitor of Plasmodium lysine tRNA synthetase based on ASP3026 (HY-13326), which has a more than seven-fold higher inhibitory effect on the growth of Plasmodium, especially Plasmodium falciparum, than ASP3026 (HY-13326). LysRs-IN-3 can be used in the development of antimalarial drugs.
    LysRs-IN-3
  • HY-12479B
    Epetraborole (R-mandelate)
    		Inhibitor
    Epetraborole R-mandelate is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole R-mandelate can be used in multidrug-resistant gram-negative pathogens infection research.
    Epetraborole (R-mandelate)
  • HY-161800
    Aminoacyl tRNA synthetase-IN-3
    		Inhibitor
    Aminoacyl tRNA synthetase-IN-3 (compound 36K3) is an inhibitor of lysine tRNA synthetase (PfLysRS) from Plasmodium falciparum (IC50=59.2 nM), which inhibits the activity of PfLysRS by occupying the ATP binding site and L-lysine binding site of PfLysRS. Aminoacyl tRNA synthetase-IN-3 can be used in the development of antimalarial drugs.
    Aminoacyl tRNA synthetase-IN-3
Cat. No. Product Name / Synonyms Application Reactivity